Semax (N-Acetyl Amidate) 10mg

Description

N-Acetyl Semax Amidate (NAS)

Enhanced Synthetic Heptapeptide Derived from Semax

Overview

N-Acetyl Semax Amidate (NAS) is a synthetic, modified derivative of the nootropic and neuroprotective peptide Semax, originally developed by the Russian Academy of Sciences. Its sequence is Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH₂, featuring an N-terminal acetylation and C-terminal amidation that improve the peptide’s stability, lipophilicity, and blood-brain barrier penetration compared to Semax. With a molecular weight of ~855 Da, NAS is water-soluble and primarily targeted to the central nervous system (CNS).

NAS is typically administered via intranasal spray (500–1000 mcg/day) or subcutaneous injection (100–600 mcg/day) in experimental or off-label contexts. It is under investigation for enhanced cognitive, neuroprotective, and stress-modulating effects but lacks formal clinical approval.

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Mechanism of Action

NAS potentiates Semax’s known effects through:

• Upregulation of BDNF and NGF: Promoting neuroplasticity and memory enhancement more robustly than Semax due to improved bioavailability.

• Monoamine Neurotransmitter Enhancement: Increasing serotonin, dopamine, and norepinephrine turnover in key brain regions, improving mood and cognition.

• Cholinergic Activation: Supporting attention and learning via elevated acetylcholine activity with extended duration.

• Antioxidant Neuroprotection: Reducing oxidative stress by inducing enzymes like superoxide dismutase and mitigating glutamate excitotoxicity.

• HPA Axis Modulation: Lowering cortisol response under stress with stronger CNS penetration.

• Anti-inflammatory Effects: Decreasing brain pro-inflammatory cytokines, aiding recovery from injury or inflammation.

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Reported Benefits

• Cognitive Enhancement: Superior improvements in memory, focus, and mental clarity relative to Semax.

• Neuroprotection: Stronger protection against oxidative damage and ischemic injury.

• Stress Resilience: Enhanced emotional stability and stress reduction.

• Mood Support: Greater mood elevation and anxiety relief.

• Neuroplasticity: Support for synaptic repair and neuronal growth.

• Longer Duration of Action: Prolonged effects allowing less frequent dosing.

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Typical Research and Off-Label Uses

• Cognitive enhancement in healthy individuals or students (intranasal doses around 500–1000 mcg/day)

• Neuroprotection post-stroke or traumatic brain injury (subcutaneous 100–600 mcg/day)

• Stress and mood disorders (off-label experimental use for anxiety, depression, burnout)

• Neurodegenerative disease models (Alzheimer’s, Parkinson’s; high doses in animal studies)

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Summary of Relevant Research

• Semax studies show memory enhancement, neurotrophin upregulation, oxidative damage reduction, and stress modulation.

• NAS’s acetylation and amidation modifications likely confer greater potency, CNS penetration, and metabolic stability, supported by anecdotal reports and preclinical rationale.

• Direct NAS-specific clinical trials are currently lacking, requiring further validation.

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Considerations and Limitations

• Safety: Appears well-tolerated with mild side effects (nasal irritation, headache) reported; long-term safety data unavailable.

• Regulatory Status: Not FDA-approved; available only as a research chemical or through specialized compounding.

• Evidence Base: Relies heavily on Semax data; NAS-specific human data are anecdotal or preclinical.

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Legal Disclaimer

This information is provided solely for research purposes. NAS and Semax are not approved by the FDA for general therapeutic or human use except in certain regulated indications. Protide Health does not endorse off-label or unauthorized use. Researchers must comply with all regulatory requirements and obtain appropriate approvals.